Our client is looking for someone who is highly accomplished in drug metabolism, with an in-depth working and theoretical knowledge of phase I and II metabolism, CYP induction and inhibition and characterization of the isoforms involved, as well as needed in vitro and in vivo methods.​ We will need this individual to be able to have a high level of expertise in either; microsomal methods of metabolism, including preparation of microsomes, or, in the cellular aspects of metabolism.​ This latter area would include metabolism studies in hepatocyte and possible other cell types.​ In this area we are interested in the metabolism of compounds, CYP inhibition, CYP induction in hepatocytes, as well as the study of phase II conjugation metabolism in cells.​ Individuals need to be able to harvest fresh hepatocytes from in situ perfused livers, and to work with the cells in/​and maintain them as primary culture or with received fresh or cryo-preserved human hepatocytes in the same manner.​