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Posted date: 2009-Aug-13
Location: Guilford, CT 06437
Our client is looking for someone who is highly accomplished in drug metabolism, with an in-depth working and theoretical knowledge of phase I and II metabolism, CYP induction and inhibition and characterization of the isoforms involved, as well as needed in vitro and in vivo methods. We will need this individual to be able to have a high level of expertise in either; microsomal methods of metabolism, including preparation of microsomes, or, in the cellular aspects of metabolism. This latter area would include metabolism studies in hepatocyte and possible other cell types. In this area we are interested in the metabolism of compounds, CYP inhibition, CYP induction in hepatocytes, as well as the study of phase II conjugation metabolism in cells. Individuals need to be able to harvest fresh hepatocytes from in situ perfused livers, and to work with the cells in/and maintain them as primary culture or with received fresh or cryo-preserved human hepatocytes in the same manner.
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